@article {1678,
	title = {Antimicrobial capacity of the freshwater planarians against <i>S. aureus</i> is under the control of Timeless},
	journal = {VirulenceVirulence},
	year = {2017},
	note = {doi: 10.1080/21505594.2016.1276689},
	month = {2017/01/04},
	pages = {1 - 10},
	publisher = {Taylor \& Francis},
	abstract = {<p>ABSTRACTPlanarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the circadian machinery in the anti-bacterial response of the freshwater planarian Schmidtea mediterranea. We identified Smed-Tim from S. mediterranea as a homolog of the mammalian clock gene Tim. We showed via RNA interference that Smed-Tim is required for the anti-microbial activities of Schmidtea mediterranea against Staphylococcus aureus infection during the light/dark cycle. Indeed, S. aureus infection leads to the expression of Smed-Tim, which in turn promotes Smed-Traf6 and Smed-morn2, but not Smed-p38 MAPK expression, 2 master regulators of planarian anti-microbial responses.ABSTRACTPlanarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the circadian machinery in the anti-bacterial response of the freshwater planarian Schmidtea mediterranea. We identified Smed-Tim from S. mediterranea as a homolog of the mammalian clock gene Tim. We showed via RNA interference that Smed-Tim is required for the anti-microbial activities of Schmidtea mediterranea against Staphylococcus aureus infection during the light/dark cycle. Indeed, S. aureus infection leads to the expression of Smed-Tim, which in turn promotes Smed-Traf6 and Smed-morn2, but not Smed-p38 MAPK expression, 2 master regulators of planarian anti-microbial responses.</p>
},
	isbn = {2150-5594},
	url = {http://dx.doi.org/10.1080/21505594.2016.1276689},
	author = {Tsoumtsa, Landry Laure and Torre, Cedric and Trouplin, Virginie and Coiffard, Benjamin and Gimenez, Gregory and Mege, Jean-Louis and Ghigo, Eric}
}
