02270nas a2200205   4500008004100000020001400041245011400055210006900169260003300238300001100271520158000282100002801862700001801890700002301908700002301931700002101954700002101975700001601996856005202012       2017                        eng d  a2150-559400aAntimicrobial capacity of the freshwater planarians against <i>S. aureus</i> is under the control of Timeless0 aAntimicrobial capacity of the freshwater planarians against iS a  bTaylor & Francisc2017/01/04  a1 - 103 a<p>ABSTRACTPlanarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the circadian machinery in the anti-bacterial response of the freshwater planarian Schmidtea mediterranea. We identified Smed-Tim from S. mediterranea as a homolog of the mammalian clock gene Tim. We showed via RNA interference that Smed-Tim is required for the anti-microbial activities of Schmidtea mediterranea against Staphylococcus aureus infection during the light/dark cycle. Indeed, S. aureus infection leads to the expression of Smed-Tim, which in turn promotes Smed-Traf6 and Smed-morn2, but not Smed-p38 MAPK expression, 2 master regulators of planarian anti-microbial responses.ABSTRACTPlanarians, which are non-parasitic flatworms, are highly resistant to bacterial infections. To better understand the mechanisms underlying this resistance, we investigated the role of the circadian machinery in the anti-bacterial response of the freshwater planarian Schmidtea mediterranea. We identified Smed-Tim from S. mediterranea as a homolog of the mammalian clock gene Tim. We showed via RNA interference that Smed-Tim is required for the anti-microbial activities of Schmidtea mediterranea against Staphylococcus aureus infection during the light/dark cycle. Indeed, S. aureus infection leads to the expression of Smed-Tim, which in turn promotes Smed-Traf6 and Smed-morn2, but not Smed-p38 MAPK expression, 2 master regulators of planarian anti-microbial responses.</p>
1 aTsoumtsa, Landry, Laure1 aTorre, Cedric1 aTrouplin, Virginie1 aCoiffard, Benjamin1 aGimenez, Gregory1 aMege, Jean-Louis1 aGhigo, Eric  uhttp://dx.doi.org/10.1080/21505594.2016.1276689