02156nas a2200241   4500008004100000020001400041245009200055210007100147260000900218300001600227490000700243520143800250100002101688700001901709700001801728700002201746700001501768700002001783700002601803700002001829700002501849856004001874       2018                        eng d  a0305-104800aPlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity0 aPlanMine 30—improvements to a mineable resource of flatworm biol  c2018  aD812 - D8200 v473 aFlatworms (Platyhelminthes) are a basally branching phylum that harbours a wealth of fascinating biology, including planarians with their astonishing regenerative abilities and the parasitic tape worms and blood flukes that exert a massive impact on human health. PlanMine (http://planmine.mpi-cbg.de/) has the mission objective of providing both a mineable sequence repository for planarians and also a resource for the comparative analysis of flatworm biology. While the original PlanMine release was entirely based on transcriptomes, the current release transitions to a more genomic perspective. Building on the recent availability of a high quality genome assembly of the planarian model species Schmidtea mediterranea, we provide a gene prediction set that now assign existing transcripts to defined genomic coordinates. The addition of recent single cell and bulk RNA-seq datasets greatly expands the available gene expression information. Further, we add transcriptomes from a broad range of other flatworms and provide a phylogeny-aware interface that makes evolutionary species comparisons accessible to non-experts. At its core, PlanMine continues to utilize the powerful InterMine framework and consistent data annotations to enable meaningful inter-species comparisons. Overall, PlanMine 3.0 thus provides a host of new features that makes the fascinating biology of flatworms accessible to the wider research community.1 aRozanski, Andrei1 aBrandl, Holger1 aMoon, HongKee1 aGrohme, Markus, A1 aHenry, Ian1 aRink, Jochen, C1 aMartin-Duran, Jose, M1 aHüttner, Katja1 aBartscherer, Kerstin  uhttps://doi.org/10.1093/nar/gky1070