TY - JOUR T1 - PlanMine 3.0—improvements to a mineable resource of flatworm biology and biodiversity JF - Nucleic Acids Researchnar Y1 - 2018 A1 - Rozanski, Andrei A1 - Brandl, Holger A1 - Moon, HongKee A1 - Grohme, Markus A A1 - Henry, Ian A1 - Rink, Jochen C A1 - Martin-Duran, Jose M A1 - Hüttner, Katja A1 - Bartscherer, Kerstin SP - D812 EP - D820 AB - Flatworms (Platyhelminthes) are a basally branching phylum that harbours a wealth of fascinating biology, including planarians with their astonishing regenerative abilities and the parasitic tape worms and blood flukes that exert a massive impact on human health. PlanMine (http://planmine.mpi-cbg.de/) has the mission objective of providing both a mineable sequence repository for planarians and also a resource for the comparative analysis of flatworm biology. While the original PlanMine release was entirely based on transcriptomes, the current release transitions to a more genomic perspective. Building on the recent availability of a high quality genome assembly of the planarian model species Schmidtea mediterranea, we provide a gene prediction set that now assign existing transcripts to defined genomic coordinates. The addition of recent single cell and bulk RNA-seq datasets greatly expands the available gene expression information. Further, we add transcriptomes from a broad range of other flatworms and provide a phylogeny-aware interface that makes evolutionary species comparisons accessible to non-experts. At its core, PlanMine continues to utilize the powerful InterMine framework and consistent data annotations to enable meaningful inter-species comparisons. Overall, PlanMine 3.0 thus provides a host of new features that makes the fascinating biology of flatworms accessible to the wider research community. VL - 47 SN - 0305-1048 UR - https://doi.org/10.1093/nar/gky1070 IS - D1 JO - Nucleic Acids Research ER -